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Sep 12 12 3:41 AM

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Reports are coming back about the use of Quinacrine - which is a quinine based drug.  Here is the Wiki article.  There are other versions of the pharma version of quinine including Iodoquinol. 


Quinacrine
From Wikipedia, the free encyclopedia
Quinacrine


Quinacrine (trade name Atabrine) is a drug with a number of different medical applications. It is related to mefloquine.

Contents  [hide] 
1 Uses
2 Mechanism
3 History of uses
3.1 Antiprotozoal
3.2 Anthelmintics
3.3 Creutzfeldt-Jakob disease
3.4 Quinacrine non-surgical sterilization for women (QS)
4 References
5 External links
[edit]Uses

Its main effects are as an antiprotozoal, antirheumatic and an intrapleural sclerosing agent.[1]

Antiprotozoal use include targeting Giardiasis, where quinacrine is indicated as a primary agent for patients with metronidazole-resistant giardiasis and patients who should not receive or can not tolerate metronidazole. Giardiasis that is very resistant may even require a combination of quinacrine and metronidazole.[1]

Quinacrine is also used "off-label" for the treatment of systemic lupus erythematosus,[2] indicated in the treatment of discoid and subcutaneous lupus erythematosus, particularly in patients unable to take chloroquine derivatives.[1]

As an intrapleural sclerosing agent, it is used as pneumothorax prophylaxis in patients at high risk of recurrence, e.g., cystic fibrosis patients.[1]

Quinacrine is not the drug of choice because side effects are common, including toxic psychosis, and may cause permanent damage. View Mefloquine page for more information.

In addition to medical applications, quinacrine is an effective in vitro research tool for the epifluorescent visualization of cells, especially platelets. Quinacrine is a green fluorescent dye taken up by most cells. Platelets store quinacrine in dense granules.

[edit]Mechanism

Its mechanism of action against protozoa is uncertain, but it is thought to act against the protozoan's cell membrane.

It is known to act as a histamine N-methyltransferase inhibitor.

It also inhibits NF-κB and activates p53.

[edit]History of uses

[edit]Antiprotozoal
Quinacrine was initially approved in the 1930s as an antimalarial drug. This antiprotozoal is also approved for the treatment of Giardiasis (an intestinal parasite),[3] and has been researched as an inhibitor of phospholipase A2.

Scientists at Bayer in Germany first synthesised Quinacrine in 1931 and subsequently marketed as Mepacrine or Atabrine. The product was one of the first synthetic substitutes for quinine although later superseded by chloroquine.

[edit]Anthelmintics
In addition it has been used for treating tapeworm infections.[4]