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I stumbled upon this site and read through it. It's actually moderated so it's a little more reliable and civil than the Curezone. Forgive me for the length. Feel free to skip to the questions at the bottom under current status. Thanks!
Pre-2002 - There is a history of digestive problems prior to my trip, but the symptoms were largely controlled once dair/gluten were eliminated from my diet.
2002 – Traveled to Central America. Fell ill from amebic dysentery. Symptoms were fever, malaise and severe diarrhea.
Treatment: Cipro and several rounds of Flagyl – severity of symptoms decreased but food sensitivities began. Flagyl made me feel pretty awful and didn't really help.
2003-2006 – continued to manage symptoms with various diets. The elimination of soy and dairy and later wheat seemed to help for a while but eventually symptoms would return. Symptoms were occasional diarrhea but mostly difficult to pass, mushy stools and frequency of defecation.
2007-2008 – began treatment with naturopath 1.
Treatment: Stool test showed candida and bacteria growth. Did a round of nyastaten, candida diet as well as supportive formulas: fiber, probiotics, herbs and vitamins. Stools returned to normal for about 3-5 months and then symptoms began to increase again.
2008-2009 – continued to treat symptoms by the elimination of foods. I had stuck to the diet free of dairy and soy with very little gluten. I went gluten free at the end of 2009 but symptoms continued to worsen regardless of what I ate.
2010-2011 – Symptoms severity began to rise again to the point that I was only eating basic foods (brown rice, chicken some greens). Began treatment with naturopath 2.
Treatment: Stole test showed evidence of bacteria, low counts of probiotics and the presence of endiomax nana and blastocystis.
Herbs – Berberine, Black Walnut and Artemesia – very little impact on symptoms.
Other – psysilium husk, saccharomyces boulardii, l-glutamine, probiotics – seem to help with diarrhea so long as I avoid carbohydrates and sugars.
Drugs combinations attempted:
Humatin (paromycin) 250mg 2 pills 3 x per day for 10 days
Iodoquinol 650mg 1 pill 3x per day for 20 days
Metagenics Canibactin BR 1 pill 3 x per day for 20 days
Cleared the E.nana, reduced numbers of Blasto, symptoms were reduced but not significantly
Secnidazole 400 mg (30 Capsules) 3 times a day
Diloxinide Furoate 500mg (30 Capsules) 3 times a day
Septrin DS (20 Capsules) 2 times a day
Symptoms improved for a period of time but over the coming months began to decline over the 8 weeks that followed. Stool test shows no reduction of blasto numbers.
5/2011 – Allergy panel and basic blood work; it all came back normal.
7/1/2011 - End/colonoscopy performed. Besides very mild inflammation everything was normal. For some unknown reason after the laxative process helped. The GI doctor said this was common but didn’t know why. The improvement was short lived. About 4 weeks after the colonoscopy symptoms began to recur. This was expected as it usually takes between 4 and 8 weeks after a treatment for the symptoms to return.
7/20/2011 - Biopsies and microscopic examination of tissues came back normal with, as the doctor put it “very, very mild” inflammation of the colon.
7/30/2011 - Obtained Rx of secondary protocol from Dr.Brody at the Center for Digestive Disease, but did not do the protocol because I wanted to speak with the infectious disease clinic.
9/2011 - Had an appointment with infectious disease clinic.
CT Scan - normal
O&P Test- (3 tests over 3 days with fixative) - results were negative for known pathogens, including Blasto.
IgA Test (celiac) - negative
HIV - negative
Since the O&P test came back negative there was no justification for the secondary protocol. I still have the medication but have not taken them.
10/2011 - Tested for CIBO at Mercy GI. Results were negative.
11/2011 - Began taking Thorne’s Mediclear plus. This provides additional relief. For a time sensitivity to fruit was reduced, but then returned after suddenly after about a month. I began experimenting with the Selective Carbohydrate diet, but I didn’t see any real improvement from it. I am able to tolerate the yogurt however.
4/2012 - Attempted fecal transplant with naturopath (Dr.Mark Davis) in the U.S. under the assumption that my issues may be due to what I'm lacking rather than what i've got. So far I haven't seen much improvement. I'm considering pursuing the infectious disease angle again. Dr.Davis suggested that I try the Metametrix testing, which seems to be highly regarded here.
Current Status: Still taking Apriso, Mediclear Plus, VSL #3, and Lomotil. Symptoms have improved some, but I’m still having trouble expanding my diet. If I stay to a very simple diet of eggs, chicken, and greens, avoid grains then I’m mostly normal.
My parasite testing was done through Genova, who I didn't entirely trust. I let the ID doctors inability to confirm the infection convince me not to take the second line treatment from CDD (now I wish I had). My reasoning at the time was that I didn't want just throw antibiotics at my system willy nilly. I figured I'd try some other things before doing that.
The second line treatment consists of: Nitazaxoanide, Secnidazole and Furazolidone. Nita and Sec didn't seem to have any extreme side effects, but Furzazolidone is supposed to be a known mutagen.
1. Is anyone up on the research about why Furzazolidone was banned from the U.S.? How dangerous is this drug really?
2. Has anyone tried (and had success) with the second line therapy. How was it? I've heard its somewhat harsh?
3. I ordered these drugs in August of 2011. As I stated, I did not take them at this time. They have an expiration date of 4/2012. This probably doesn't need to be asked, but are they still good? I'd prefer not to have to re-order the drugs all over again (but if I have to I will).
4. If and when I do attempt the second-line protocol, can you give me some suggestions to help the treatment take?