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Serrapeptase enzyme may be effective against biofilms.
Serrapeptase teamed with antibiotics delivers increased concentrations of the antimicrobial agent to the site of the infection.
In an attempt to prevent this bacterial immunity, researchers have experimented with various means of inhibiting biofilm-embedded bacteria. Bacteria often endure a process called biofilm formation, which results in resistance to antimicrobial agents.
One study conducted by Italian researchers suggests that proteolytic enzymes could significantly enhance the activities of antibiotics against biofilms.
Antibiotic susceptibility tests showed that serratiopeptidase(Serrapeptase) greatly enhances the activity of the antibiotic, ofloxacin, and that it can inhibit biofilm formation. [Antimicrob Agents Chemother. 1993; 37(12): pp.2618-21]
Another double-blind randomized study evaluated the effects of administering the antibiotic cephalexin in conjunction with serrapeptase or a placebo to 93 patients suffering from either perennial rhinitis, chronic rhinitis with sinusitis or chronic relapsing bronchitis.
The serratia peptidase treated group experienced significant improvement in rhinorrhea, nasal stuffiness, coryza and improvement of the para-nasal sinus shadows.