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Sep 20 10 10:44 PM

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Homeostatis:   Wikipedia defines homeostatis as :

"Homeostatis refers to the body's ability to physiologically regulate its inner environment to ensure its stability in response to fluctuations in the outside environment and the weather. The liver, the kidneys, and the brain (hypothalamus, the autonomic nervous system and the endocrine system[1]) help maintain homeostasis. The liver is responsible for metabolizing toxic substances and maintaining carbohydrate metabolism. The kidneys are responsible for regulating blood water levels, re-absorption of substances into the blood, maintenance of salt and ion levels in the blood, regulation of blood pH, and excretion of urea and other wastes.
An inability to maintain homeostasis may lead to  disease, a condition known as homeostatic imbalance. For instance, heart failure may occur when negative feedback mechanisms become overwhelmed and destructive positive feedback mechanisms take over.[2] Other diseases which result from a homeostatic imbalance include diabetes, dehydration, hypoglycemia, hyperglycemia, gout and any disease caused by the presence of a toxin in the bloodstream. Medical intervention can help restore homeostasis and possibly prevent permanent damage to the organs."
http://en.wikipedia.org/wiki/Human_homeostasis
 
Well this is quite a mouthful :(    Basically what they are saying is that when the body is met with a challenge say extreme heat or infection that the body must make changes in order to adapt to that stress.  

In order for the body to make changes, it must shift biochemical balance.  For instance say you are walking down a dark alley by yourself and you hear footsteps behind you.  This is a stress, it is a fear reaction and the body will make changes in order for you to cope with that situation, the fight or flight syndrome (http://en.wikipedia.org/wiki/Fight-or-flight_response).   First you process the information that you are encountering trouble (sound of the footsteps etc), this signals parts of the brain which signals the hypothalamus/pituitary which are hormone signal senders one of which is ACTH.   The ACTH gets sent out like a messenger into the bloodstream and when these molecules reach the adrenals, it tells the adrenals to secrete hormones.   There are many hormones that the adrenals secrete but probably the most important is  adrenaline and cortisol.  

These hormones then get released into the bloodstream to ready the body for fight or flight.  For instance these would help your eyesight and hearing to become more acute, increase the heart rate in order to get more blood flowing to the muscles and affect the nervous system to become more alert.  

You could liken these homeostatis reactions to a car climbing a hill.   Well on flat ground or going downhill your car can navigate this much easier than going up a steep hill pulling a trailer.   In order to meet this challenge the car will use more resources quickly such as gas.  It also puts more stress on the engine,  transmission etc.

Back to the infections, when the body is stressed by infections, major changes occur in the body when dealing with this situation.  If the proper resources (nutrition) is not supplied then the body becomes weaker.   I hope to explore some of those systems in the following posts.  


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Sep 21 10 2:43 AM

**note that this is a work in progess :) **
 
 
IMMUNE RESPONSE::
 
Overview:
An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own healthy cells and tissues in order to function properly. Detection is complicated as pathogens can evolve rapidly, and adapt to avoid the immune system and allow the pathogens to successfully infect their hosts.

from Wikipedia http://en.wikipedia.org/wiki/Immune_system

The immune system is a complex system that involves many processes, it is closely linked with endocrinological responses which helps explain adrenal exhaustion, liver toxicity, blood sugar issues, thyroid involvement, gonadal and hypothalamus/pituitary. 



Nutrients:

Amino Acids:

Minerals:

Magnesium

Copper

Zinc

Manganese


Vitamin Co-factors

Vitamin A (Beta-carotene and other carotenoids)

Vitamin D3

Vitamin C

Bioflavanoids

The following is from Whole Foods http://www.whfoods.com/genpage.php?tname=faq&dbid=24

Protein and your immune system
Much research has shown that protein malnutrition can have a variety of untoward effects on the immune system. In fact, protein malnutrition may be an important contributing factor in HIV seroconversion (the process by which a person with primary exposure to Human Immunodeficiency Virus becomes infected with that virus). Research studies have show that deficiency of high-quality protein protein can result in depletion of immune cells, inability of the body to make antibodies, and other immune-related problems. In addition, animal studies have shown that the immune system can be significantly compromised with even a 25% reduction in adequate protein intake.

Protein is composed of the 20 amino acids your body needs for growth and repair, and some of these amino acids appear to be particularly important for immune functioning. For example, the amino acids called glutamine and arginine are being considered as nutrition therapy in pre-surgery patients because of their ability to stimulate the immune system. Interestingly, it is not just deficiency of these amino acids that can compromise the immune system, an imbalance in the ratios among amino acids can also affect the immune response.

Therefore, a diet that supports a healthy immune system should contain foods providing high-quality, complete protein, such as that found in eggs, fish, shellfish, and venison. Many vegetables and grains are also excellent sources of many of the immune-stimulating amino acids and, together with other protein sources, are particularly beneficial. The recipes on this web page provide many excellent menus for a meal with complete protein, such as the Baked Seafood with Asparagus, or Poached Fish with Chinese Cabbage.

The essential vitamins for healthy immune function
As discussed above, your body uses a variety of responses to maintain its defense against harmful pathogenic organisms in the environment; therefore, it may not be surprising that nearly all of the vitamins are necessary to maintain and promote some aspect of your immune function. Some vitamins have received more attention in the research literature since they are particularly important to a healthy immune system.

Much has been written about the role of vitamin C in supporting the immune system, in part because it has been promoted as an immune stimulant by the noted scientist and Nobel Prize Laureate, Linus Pauling. Vitamin C appears to support a decrease in the length of time and severity of symptoms associated with upper respiratory viral infections, promote phagocytic cell functions, and support healthy T-cell function. Vitamin C also provides antioxidant activity to support healing at sites of inflammation. An excellent source of vitamin C is citrus fruit. Many vegetables are also excellent sources of vitamin C, such as fresh parsley, raw cauliflower, mustard greens and Romaine lettuce.
Many of the B-vitamins are also very important in supporting a healthy immune system. For example, vitamin B5 (pantothenic acid) promotes the production and release of antibodies from B-cells, and deficiency of vitamin B5 results in reduced levels of circulating antibodies. Folic acid deficiency leads to a decrease in T-cells and can result in reduced effectiveness of the soluble factors as well. Vitamin B6 deficiency consistently impairs T-cell functioning and results in a decrease in blood lymphocyte counts. Deficiencies in vitamins B1(thiamin) and B2 (riboflavin) may impair normal antibody response, and low vitamin B12 appears to inhibit phagocytic cells and possibly T-cell function.

Almost all whole grains, vegetables and fruits can serve as excellent sources of at least some of these vitamins, but some vegetables are particularly beneficial since they are excellent sources of many of these immune-supporting vitamins. In particular, Romaine lettuce is an excellent source of vitamins B1, B2, C, and folate. Cooked turnip greens and boiled spinach are excellent sources of folate, vitamin B6 and vitamin C. And cooked cauliflower is an excellent source of vitamin C and folate and a very good source of vitamin B5 and B6. Raw crimini mushrooms are also an excellent source of vitamin B2 and vitamin B5. Red bell peppers are an excellent source of vitamin B6. Vitamin B12 can be obtained from protein-providing foods such as fish, shellfish, venison and calf's liver.

The fat-soluble vitamins, vitamin A, vitamin E and vitamin K are also important to overall health. Vitamin A deficiency has been shown to impair antibody function and T-cell activity. Vitamin E is an important antioxidant and supports a healthy inflammatory response. Vitamin E is also an important component of all cell membranes and promotes healthy cellular functioning overall. T-cells and B-cells from vitamin E-deficient animals show depressed responses, and tumors have been shown to grow faster in vitamin-E deficient animals. Vitamin K supports a healthy blood-clotting ability in your body, and this is necessary for seclusion of areas of infections and injury in the healing process. Cooked turnip greens and boiled mustard greens, mentioned above, are also excellent sources of vitamins E and A, as well as boiled Swiss chard. Other excellent sources of vitamin A include many vegetables such as spinach, fresh parsley and carrots. Concentrated sources of vitamin K include raw cauliflower, as well as most green vegetables such as spinach and asparagus.

Minerals that support your immune system
Zinc is one of the minerals in food that has received the most attention for its ability to support immune function. Zinc is a potent immunostimulant, and its deficiency can result in profound suppression of T-cell function. Children with severe zinc deficiencies show signs of growth retardation and susceptibility to infections. However, an excess of zinc has also shown negative effects on immune function and can inhibit the phagocytic cells (macrophages and neutrophils). So, maintaining adequate but not excessive levels of zinc is important. This is one reason food is such an excellent source of obtaining nutrition versus supplementation; food contains a balanced variety of the micronutrients whereas supplementation with individual nutrients can lead to too much of some and not enough of others. Healthy levels of zinc can be provided by including the good sources of zinc, such as boiled Swiss chard, collard greens, and both summer squash and winter squash, or the very good or excellent sources of zinc like lamb, raw crimini mushrooms and calf's liver in your diet.

Many other minerals are important in supporting immune function. Clinical research studies have shown that iron deficiency results in impaired response to antibodies, and defective phagocytic cell functioning. Copper deficiency is associated with an increase in infections and may impair development of immune cells such as T-cells and the phagocytic cells. Selenium and manganese are important for supporting healing from inflammation and may be immunostimulants. Selenium can be obtained from fish and shellfish, as well as tofu and whole grains. Excellent sources of copper are turnip greens, calf's liver and raw crimini mushrooms, and very good sources include spinach, asparagus and summer squash and boiled Swiss chard. Iron can be provided by fresh parsley, spices such as thyme or cinnamon, tofu, beans and peas, and many other vegetables such as spinach and Romaine lettuce.

Antioxidants and phytonutrients that promote healthy immune function
Reactive oxygen species, free radicals and other damaging molecules are generated at sites of infection and inflammation. Your body needs these molecules at the site of infection to help kill unhealthy cells; however, when your antioxidant systems are not functioning, or when not enough antioxidants are present in your diet, these molecules are not disarmed after they have done their jobs and can become damaging to healthy tissue as well. Many fruits and vegetables provide antioxidants and phytonutrients that help maintain healthy tissue around the sites of infection and support healing. Fruits and vegetables, especially colored foods like strawberries, cherries, carrots, and tomatoes contain many beneficial phytonutrients with antioxidant potential. More detailed information on the health benefits of phytonutrients can be obtained from the FAQ: "What is the Special Nutritional Power Found in Fruits and Vegetables".

Are there foods that are bad for my immune system?
Your immune system is not just involved in fighting invaders like bacteria, but also becomes activated when you eat foods to which you are intolerant or allergic. Reactions to allergic foods can be quick, like the anaphylactic reaction often seen with peanut or shellfish allergies, but food allergy reactions can also be delayed and cause a number of symptoms like headaches, fatigue, muscle aches, rashes and other systemic (whole body) effects. The most common allergenic foods include peanuts and shellfish, cow's milk, wheat, and soy; however, everyone is unique in their food intolerances and allergies.
Processed foods and foods produced with pesticides or not grown organically may also be problematic for your immune function. Toxic metals such as cadmium, lead and mercury are immunosuppressive. Some pesticides and preservatives can negatively effect the gastrointestinal lining. Food additives can also have untoward effects on the nutrient content of the food. For example, sulfites destroy thiamin-vitamin B1 in foods to which they have been added.

How do I keep a healthy "balance" in my immune system?
Your immune system is developed to be able to kill cells, such as bacteria cells or viruses; your immune cells can act against cancer cells within your body as well if it is able to tell that these cells are unhealthy to you. However, without proper control and the ability to differentiate healthy from unhealthy cells, your immune system can mistakenly kill your own healthy cells. Your inflammatory response is also developed to support healing, but when this response becomes overly active, it can become destructive. Autoimmune system diseases like rheumatoid arthritis and multiple sclerosis, susceptibility to infections, and wounds that won't heal are some of the repercussions of immune system imbalance and dysfunction. Therefore, healthy immune and inflammatory responses must maintain a delicate balance to achieve protection without causing self-destruction.

Your body has a complex means of recognition on your cells' membranes to help your immune system. Some specific soluble factors of your immune system are also involved in turning-off your immune response. How well these responses function is defined in part by your genes; however, recent research has suggested that diet plays a much larger role in autoimmune system dysfunction than was once thought. For example, research has shown an association with low levels of vitamin D and increased risk of some autoimmune diseases, such as multiple sclerosis. Concentrated sources of vitamin D include cow's milk eggs and shellfish such as shrimp and fish such as cod.
The omega-3 fatty acids, which are produced in your body from the essential omega-3 fat - alpha-linolenic acid - have been studied for their effects on the immune system and inflammatory response. Diets low in omega-3 fatty acids are associated with chronic inflammatory conditions and autoimmune diseases. In order to achieve a more beneficial ratio of omega-3 fatty acids in your body, it is important to decrease the amount of omega-6 fatty acids in your diet, while increasing the amount of omega-3 fatty acids. This can be accomplished by reducing your consumption of meats, dairy products, and refined foods, while increasing consumption of the omega-3 rich foods such as wild-caught cold-water fish like salmon, flaxseed oil, walnuts, and leafy green vegetables.





 





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ADRENAL RESPONSE:
Dr. Hans Selye is considered the father of the adrenal studies.   Selye did much important factual work on the  response of the organism to stressors.  Stress can be defined as the general strain on the body caused by disease, injury or mental pressure.   Typically stress is usually understood as mental stress with little emphasis on biological stress.   Biological stress may be a more important role in health or disease.  I would define biological stress as stressors that are affecting your body and not your mind.  Examples of this would be infections, toxins, inadequate nutrition, burns, trauma and a lack of water and a lack of sleep. 
As stated previously, homeostatis is the ability for the body to respond to changes such as heat or cold.  The body makes changes to the system to adapt.  For instance you begin to sweat which cools the skin, you begin to feel thirsty so you drink water to cool the body.   In essence your body is self-regulating, in other words you are not consciously aware of these changes. 
The adrenals play key roles in the adaptive process (stress).  Wikipedia defines the adrenals as
The adrenal glands (also known as suprarenal glands) are the triangular-shaped endocrine glands that sit on top of the kidneys. They are chiefly responsible for releasing hormones in conjunction with stress through the synthesis of corticosteroids and catecholamines, including cortisol and adrenaline (epinephrine), respectively. Though connected to the kidneys, these glands play no role in the functioning of, or health of the kidneys. Glands are part of the endocrine system, and kidneys are part of the urinary system.
 
 
 

 
Traditional medicine recognizes two primary problems with adrenals
1)  Addison's Disease  (underproduction of hormones)
2) Cushing's Disease (overproduction of hormones)
These are extreme conditions of adrenal disease, however Alternative medicine has identified that there can more subtle issues, Adrenal Fatigue (AF) is one of those. 
Adrenal Fatigue (AF)
AF would best be defined as a weakening of the adrenals.   In other words you beat them and now they are tired :).   And I would add that there is another condition in which the adrenals are ok but are lying dormant, this is really not an issue with people with infectious issues so I will not be covering this. 
Some of the signs of AF are:   fatigue, exhaustion, diminished coping of stress, brain fog, concentration problems, hormonal disturbances, low immunity, depression, anxiety and irritability, diminished vitality etc.
I went into full blown Cushing's following my infection with the protozoa parasites which is quite rare, there was only one physician that would acknowledge the fact that this type of adrenal response could occur with infections, it is not widely known just showing up in one endocrinology textbook I found.   But Cushing's is extreme and will lead to AF pretty fast.   I experience horrid anxiety and depression, swelling of my neck, feet and hands, muscle pain and horrible fatigue.   I continued to take my nutritional supplements that I was on previous to the onset of Cushing's, then I stopped for about 2 weeks thinking that it was bunk.   Well that was a big mistake, within a short period of time (2 weeks) I began to have extreme panic attacks and for those who have suffered panic attacks, I don't need to say anything else.   The panic attacks became stronger and on a January Friday morning I found myself collapsed on the living room floor unable to get up gasping for breath and a heart pumping a million beats a minute.   Terror enveloped me, I felt crazy.     I called my family to come from work.  They drove me to the ER, I rode in the back thinking they were going to put me in the psychiatric ward.   Well you know how it goes, the ER doctor gave me anti-anxiety drugs which never solved the problem. 
I woke up the next 2 days feeling like someone was putting an electrical current thru my body, the sound of a vacuum cleaner made me crazy.   I started back on my nutritionals and began combing thru my nutritional literature hoping that someone would address this problem with no such luck.  I began dosing with green drinks and bananas hoping to get electrolytes into my body, I then began to stablize but the panic attacks continued, although not as strong.  
By a sheer act of God, my mother called me (as I was still bedridden) and read a chapter out of a book from Adelle Davis http://www.amazon.com/Lets-Well-Signet-Adelle-Davis/dp/0451154630   This chapter was about Stress and the adrenals and research from Selye and also nutritional models.   I began to follow her advice and got the adrenals to stablize and with the stablization of the adrenals, the other systems began to stablize as well.  
Remeber that the adrenals are the manufacturers of vital hormones.  Some of the hormones are:
1/  Glucocorticoids
2/  Catecholamines:
   a.  Epinephrine (Adrenalin)
   b.  Norepinephrine
3/  Mineralcorticoids
4/  Androgens
Repair of the adrenals:
Nutrition always plays key roles in restoration of health afterall every cell in your body is dependent on building blocks.   I will take a few pages out of my experimentation.  
  B Vitamins
  -Pantothenic Acid 
 is also known as Vitamin B5 and like other b vitamins plays important roles throughout the body.   A study was done by volunteers (actually prisoners) in which all panthotenic acid was removed from their diet.  Within a short time (2 weeks?) they went bonkers and they had to call the study off.      They were placed on large doses of supplemental pantothenic acid and recovered very slowly.  Panthothenic acid is stored in the adrenals and plays a key role in keeping them healthy.    
  -B2/B6
*edit
  - Vitamin C
Vitamin C cannot be manufactured in the human body although it can be in animals.  Scurvy is a well known deficiency of vitamin C and more recent discoveries about it show conditions like arteriosclerosis as conditions of deficiency as well.   Vitamin C is well known as a free radical scavenger (antioxidant) and in my opinion the best antioxidant I have ever taken.   Studies show that the adrenals and vitamin C are closely associated, Adelle Davis published research showing without adequate vitamin c that the adrenals begin to shrivel and hemmorage. 
   Essential Fatty acids
 
 
   Magnesium
Magnesium is the overlooked mineral and why that is, is unknown to me.   It plays very key roles in over 350 enzymatic functions within the body and would be considered the mineral to maintain homeostasis.  Magnesium is a tricky mineral in that it can be difficult to absorb it unlike other minerals such as potassium.   It also is subject to wasting - usually due to endocrine disturbances such as diabetes and adrenal dysregulation.  
Dr. Mildred Seelig wrote some of the most important journal articles on magnesium and its role in cardiovaascular, immune and stress reactions.  It has been shown that under most stressors that magnesium is lost.   These stressors include loud noises, heat and cold extremes, infections, burns and traumas.   This why stress and cardiovascular problems are associated and you can also make a simple jump of logic to associate stress with cancer.   These problems (and others) can be traced back to the magnesium depletion. 
Seelig made associations with adrenal stress and magnesium as well.  These assocations work in both directions that is that adrenal stress will reduce magnesium stores and reduced magnesium stores will encourage adrenal stress.  
So it is very important that those who are suffering with adrenal issues from these parasites look to magnesium to help them.   It is important to use the correct forms and to avoid those forms that are not bio-available such as magnesium oxide.   My best results have come from 2AEP Magnesium, UltraMag from Source Naturals, magnesium chloride (SlowMag etc) and I like LEF magnesium.   It is also important to have your Vitamin D3 levels checked as this vitamin works with magnesium.   And of course the latest research on Vitamin D shows its role in the immune system and neurological.  See vitamindcouncil.org for more information. 
  Glandulars.
 
 Glandulars are not used in America as they are in Europe.   They played a key role in my adrenal healing, the other nutritionals stabilized the adrenals but the glandulars healed them.   This product is made by many manufacturers and I would recommend staying away from those that contain licorice which have a stimulating effect which is not good for people with adrenal exhaustion. 
 
 
-Protein
 
Protein plays key roles in the repair of the body and the adrenals are no exception.   Every cell of the body is dependent on protein.   Protein is made up of amino acids, the body uses these amino acids for most of its operation.  
Proteins are the basic building blocks of the entire body. Their assimilation and utilization are controlled by the DNA. Basically when you ingest proteins, the body begins to pull apart the bonds of the proteins using enzymes to accomplish this. ((hydrochloric acid and pepsin are secreted by the stomach then some of the pancreatic enzymes will further break down the proteins)).
Regardless of the protein source, all the proteins are basically amino acids that are attached in very complex manners. So the body takes for example chicken which is for demonstration purposes is a amino acid complex of lysine, methonine and taurine (for example only). So when you begin to chew the chicken then you are starting to break down the proteins, then the stomach secretes its enzymes and further breaks down the protein and finally the pancreatic enzymes break it down even further. They get broken down to their individual amino acids. Now that the amino acids are freed up the body begins to reassemble the amino acids into what the body needs it for, these are called proteins.
This is where the DNA comes in. It is like the software of your body and begins to build proteins for specific purposes by assembling different amino acids . Proteins for the eyes and proteins for the immune system are different, they require different components like baking a chocolate cake requires different ingredients than a pineappple upside down cake, they are both cakes but use some similar ingredients like flour and sugar but have differing ingredients thus their outcomes are different.
So for instance immune cells require more cysteine than say the eyes. Taurine and methonine are probably more predominant in the liver than say lysine. Lysine is involved in calcium/magnesium retention and threonine is involved in immunity.
But the DNA and I guess RNA will decide where to put those molecules. And I would say that the body is an incredible machine which makes me believe in Intelligent Design.
But if there are other componenets that are missing say Zinc then the DNA may not be functioning properly as zinc is involved in protein assimilation. But zinc is not the only thing involved. Vitamin co-factors such as B6 are involved in protein assimlation as well along with the proper minerals.
Toxicity will interfere with protein assimilation particularly heavy metals such as lead.
So to make a long story short, mineral and vitamin or nutrient deficiency can cause protein assimilation problems along with heavy metals.
I had terrible ridging in my nails and looking at them today they are much better. My personal opinion in this has to do with the detoxifying I did which I would say ozone was the big gun in that. Ozone will provoke toxin release and I used other toxin vacuums like chlorella, edta and other stuff (I like zeolites, I use ACV zeolite from rnaresults.com) I had horrible reactions which was toxin release, I think metal releases.) If you want more info on this protocol let me know.
A really good test to use is the Amino Acid profiles from Metametrix. I had a urine test done from Genova, but then I did another test from Metametrix and was blessed to speak to their main guy Dr. Lord. He has the killer book on orthomolecular studies but it is expensive. He was very generous and told me that serum testing is the only way to test not urine. They offer a few levels of testing. But anyhow testing goes a long way for instance my test showed issues with the 3 majors >>> cysteine, methionine and taurine. And the commonality with these is they are all involved in 2 major things ::: detox and immune system. Other tests from other patients show that this is common among those with pathogenic loads.
Here is an additional link with some very good information on it concerning the adrenal responses:
http://www.tuberose.com/Adrenal_Glands.html
 


**edit   (((page is still under construction)))))))))
This video covers some key points about adrenal function and it is my opinion that products listed may not be enough to restore the adrenals.  



Adaptogens::


Adaptogens are herbals that help moderate the harmful effects of stress on the body, they not only lessen stress but protect organ systems and help tonify the body to aid in the fight or flight syndrome.   Examples of adaptogens would be Siberian Ginseng, Ashwaghanda and Jiagoluan and I think that Turmeric could be classified as an adaptogen as well.   Some herbs that are listed as adaptogenic can also have stimulatory effects such as Ginsengs with the exception of the Siberian variety.  I would also stay away from Licorice which in itself has many great qualities, but does have a tendency to stimulate the adrenal glands, so if you are suffering with overactive adrenals, which many do with these infections, then using licorice will further provoke the adrenals which is not a good idea.   I purchase these items in bulk which saves a great deal of money.  






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LIVER::

The liver is always going to be an issue for people suffering with immune difficulties.  One of the bigger things I found was the role of Glutathione in these conditions.  Glutathione is considered one of the master detoxifiers of the body.  It is a tri-peptide meaning that 3 amino acids are necessary for its production, cysteine being one of them.

Glutathione has a dual-role.
1)  It is a detoxifier of many substances, utilized in the liver etc.
2)  It is a key component of the immune system.

My theory is this::  We become vunerable to disease when glutathione stores become depleted.   If you are attacked with toxins (particularly heavy metals such as mercury, which by the way attack the thiol groups of amino acids in which the key amino acid cysteine is part of the thiol groups) then glutathione is depleted.   By depleting glutathione then the immune system becomes weakened.  When the immune system becomes weakened then become more vunerable to pathogenic attack.   So if we become weakened with pathogenic attack then glutathione stores are depleted which leaves us vunerable to toxins.  And the cycle continues until either the body becomes rebalanced with nutritionals such as vitamin C, magnesium, b vitamins, essential fatty acids etc., or the pathogenic invasion is stopped or toxins are removed or any combination.

http://www.articlesbase.com/wellness-articles/what-doctors-are-saying-about-glutathione-991294.html

The problem with glutathione supplements is that since it is a tri-peptide, if taken orally, then stomach acids will attack the tri peptides which lead them non potent.  I use a product that is protected by liposomes which is the latest greatest product, it is called Readisorb*.   Cysteine is another choice that is quite good.

*If anyone is interested in Readisorb,   I can obtain this wholesale and pass on the savings - cost would be $40 per bottle versus $65 wholesale.   (I would state that I am not posting info about this to profit from it)   PM me if interested. 

Another option would to use NAC or cysteine, the latter being the cheaper method.  But you would need to use with the methylation co-factors as outline below.
Also methylation I think plays a key role in liver health

Methylation
Methylation involves conjugating methyl groups to toxins. Most of the methyl groups used for detoxification come from S-adenosylmethionine (SAM). SAM is synthesized from the amino acid methionine, a process which requires the nutrients choline, the active form of B12 --methyl cobalamin, and the active form of folic acid --5-methyltetrahydrofolate. SAM is able to inactivate estrogens (through methylation), supporting the use of methionine in conditions of estrogen excess, such as PMS. Its effects in preventing estrogen-induced cholestasis (stagnation of bile in the gall bladder) have been demonstrated in pregnant women and those on oral contraceptives. In addition to its role in promoting estrogen excretion, methionine has been shown to increase the membrane fluidity that is typically decreased by estrogens, thereby restoring several factors that promote bile flow. Methionine also promotes the flow of lipids to and from the liver in humans. Methionine is a


major source of numerous sulfur-containing compounds, including the amino acids cysteine and  taurine.



I also use (or have used)::

1) Herbal cleansers. Milk thistle with dandelion has long been used for liver support. There is plenty of documentation about the active ingredient in milk thistle and its positive effect on the liver. I use a combination blend with Bupleurum http://www.iherb.com/planetary-herbals-bupleurum-liver-cleanse-530-mg-150-tablets/1511?at=0
There is another product called Liv52 that seems to have good reviews.
2) I also use and have used polyphosphatidylcholine or phosphatidylcholine or PC or lecithin which are all the same. And listed best to lesser value. I don't know if the action of PC is due to the choline part (which was covered in the previous post about choline's ability to help in methylation) I do know that Patricia Kane PhD is crazy about this supplement (she uses polyphosphatidylcholine which is a bit more pricey) stating that the cell membranes are comprised of PC and become damaged in high oxidation therefore the cells become damaged.
Here is an article on PC and liver health::
http://www.nu-liverpc.com/liver-protection-pc-2.htm

Lastly I went to a Chinese Medicine doctor (actually 2 of them) who both confirmed liver congestion. The one stimulated the LIV 1, 2, 5 (I think). There are several Chinese thoughts on the liver meridian and here is a link for those:: http://www.yinyanghouse.com/theory/chinese/liver_meridian_disharmonies#excess-lvqistag

I used an Acupen which is a electric stimulator (which has no pain) on the liver points for some time. Although I think it would be best to confirm which liver condition you have. Another great source is Acumedico.com, they have many resources there. I am know that the Chinese have herbal formulas for this and I am sure they use bupleurnum as mentioned above. Perhaps a trip to a TCM doctor might be best.

Additional reading >  http://biologyofkundalini.com/article.php?story=LiverDetoxification


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OXIDATION:
 
What is oxidation:
 
Oxidation is a chemistry term to describe chemical reactions, it is associated with free radicals or free radical damage.   Antioxidants reduce the amount of oxidation.   Oxidation (free radicals) normally occurs under normal body processes but is accelerated with immune system activation such as those fighting parasites.  It is important to control the free radicals as damage occurs to the body from these and will reduce your vitality (immune system, glandular functions etc).

 
Oxidative damage:
Oxidative damage occurs within the body which damages the body, organ systems and cellular functions.   There is very supportive evidence that the cell membranes of which there are trillions of in the body become damaged under oxidative stress which damages much of their function.   Both Majid Ali, MD and Patricia Kane PhD have written extensively of this phenomena.   When the cell membranes become damaged, they can no long perform the functions as they once did.  Repair of the cells becomes important.   
Dr. Ali states in his book "Canary and Chronic Fatigue" that the cells become 'leaky' and are unable to hold magnesium and potassium which are both intracellular minerals.  Both of these minerals are vital for proper health, of most importance is magnesium which controls 350+ enzymatic functions.   Dr. Mildred Seelig MD stated in her article concerning chronic fatigue syndrome that magnesium plays a key role in this disease.   And I should state that CFS is a broad term in which there can be many infectious organisms including parasites that play a role in it.  
The cell membranes are mainly comprised of phosphtidyl choline (PC) which is a fatty acid (fat).   Primary sources of this is lecithin, however there are products that contain more PC than lecithin such as PC35 products which are more economical that polyphosphitdyl choline (PPC) which is a powerhouse of PC but can be quite expensive.   
It is thought in chronic cases that PPC should be used.   I used quite a bit of it and I believe that it helped me a great deal.   
 
 
Stopping the oxidative state:
Any antioxidant will be helpful and antioxidants come in many forms such as vitamin C, E and A.   I prefer ascorbates as the form of vitamin C as they are less acidic. And people with these infections are going to be more acidic rather than alkaline.  The more acidic you are, the more pain and fatigue you are going to have.   I find that using simple baking soda which is known as sodium bicarbonate is quite effective in reducing acids.  You might want to be careful of the added sodium in baking soda, the other alternative is potassium bicarbonate in which you would used 1/2 of the dose compared to baking soda.  
I like many herbs such as turmeric which has been shown to protect the cardiovascular system etc and has been shown in studies to provide anti cancer activity.   There are a number of other herbs besides turmeric such as rosemary, cinnamon and cloves and I am sure there are many others as well.   
Glutathione plays  a very key role in reducing oxidation.   I have experimented with many forms of which I would highly recommend the liposomal form which will not be degraded by stomach acids like other forms.  It is a little expensive but the benefits far outweigh the cost.   
 
 

 


  Superoxide dismutase is another potent anti oxidant but again I found the oral supplements to be lacking. (Update:  Solaray produces a SOD that is enteric coated which means it can survive stomch acids thus protecting the integrity of the supplement)  I have tried the newer formulas to some success but I was able to track down a liposomal form which was hard to get and it gave me good results.  
(liposomal delivery systems are far superior to any other method)


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