Remove this ad

Lead

Feb 28 16 2:26 PM

Tags : :

I posted this on another forum and thought it would be an interesting read for some.  I have research to back just about every part of this finding the most important part this morning.  It will be linked. 

I believe in my situation, a vector borne disease caused an increase in inflammation due to LPS detection and the constant cytokine cascade created so much quinolinic acid that it lowered the synovial and interstitial pH which allowed increased bacterial growth. This snow balled into a metabolic nightmare and the only way my body could cope was through epigenetic shifts to up and down regulate genes. Combined with my high protein intake, the homozygous shifts occurred in the CBS and MTR/MTRR. My MTHFR and BHMT's may have already been heterozygous (caffeine issues). The reason these genetic shifts occurred was due to substrate and catalyst depletion. The initiation of the cytokine cascade occurs when putrescine is protonated to spermidine and travels through the cell membrane to begin the cascade. Spermidine is converted to spermine under acidic conditions and their metabolism rate is self limiting. These polyamines are bound to large, negatively charged compounds like DNA, RNA, cyclic-AMP, etc. The transport of these agents is possible because of substrates which are mostly various polyvalent cations. Polyamines are intracellular existing proteins with only about 15% existing extracellularly. Due to the low pH and available hydrogen atoms, the rate of spermine conversion back to spermidine is decreased and intracellular transport is not possible. The nitric oxide which was produced during the cytokine cascade then helps eliminate the spermine. The problem occurs because when this spermine is eliminated, so are the catalysts and substrates bound to it. I believe them to be manganese, magnesium, copper, molybdenum, selenium, and perhaps boron. I don't believe zinc or calcium are depleted but can't explain why I think that. So now I'm in a situation where my biological pathways are functioning much less efficiently in addition to the pathogens that started the entire process. The way I improved was to decrease my pathogen load and slowly increase nutrient/mineral intake. I will never be where I once was, but I can live what most people would call a normal life. Any thoughts to this?

http://www.sciencedirect.com/science/article/pii/0166685187901058
Quote    Reply   
Remove this ad
Remove this ad
avatar

linenup

fanatic

Posts: 1,685

#1 [url]

Feb 29 16 4:11 AM

Thanks for posting, obviously you are  well educated and present ideas that challenge us. Let me try to break down what you are saying and correct me where I error. 

I believe in my situation, a vector borne disease caused an increase in inflammation due to LPS detection and the constant cytokine cascade created so much quinolinic acid that it lowered the synovial and interstitial pH which allowed increased bacterial growth.

>A vector borne disease would be a pathogen that is transmitted from one species to us humans. For instance Malaria is transmitted from certain species of mosquitos, another would be Lyme disease which is transmitted via ticks. However science is now recognizing that other pathogens that were not understood can be transmitted from animals or insects. 

 which allowed increased bacterial growth.


>Many of these complex diseases such as Lyme refer to 'co-infections' which can be translated to other immune type of diseases. The idea would be that when someone is infected with a hardy infection that the immune system is so busy with the primary infection that it leaves gaps in the immune response which allows other pathogens to migrate. Viruses would be another possiblity. And it would be possible that a viral agent may have been present prior to the difficult infection. 

This snow balled into a metabolic nightmare and the only way my body could cope was through epigenetic shifts to up and down regulate genes

>This is exactly what happened to me, I went into a complete disarray metabolically with the infection. My entire endocrine system went bonkers which included adrenals/pancreas/liver going into overdrive. So the epigenetic shifts were there to try to provide stabilization to the system (homeostatis),.

The rest of the post is unknown territory for me but I think you are saying that the event (infection) cascades into a number of issues (chain reaction). Killing the infection stops the cascade. In my case this is very true, as the infection has lessened, so has all the nasty side effects. Which for me are endocrine, neurological, connective tissue, sleep, fatigue etc. Nutrient intervention is a must with an emphasis on reducing the oxidation and keeping the liver open, the adrenals supported. Of course we need as much psychological help to stop the waves of hopelessness, depression and anxiety. I have found that cognitive modification is helpful. The mind will trigger the body's systems and we need to stop those draw downs. 

 

Quote    Reply   

#2 [url]

Feb 29 16 6:51 AM

Your assessment is correct.  The major obstacle for me is that I can not eliminate my main pathogen.  It is a protozoal parasite (apicomplexan) that seems to harbor in the extracellular matrix and in biofilms.  Mepron worked but was not curative.  Cryptolepis and artimesia worked but were not curative.  Green tea and black walnut worked but is not curative.  Any napthoquinone derivative or polyphenol works but is not curative. 

The best thing I have found is to rid myself of the other problems like yeast, metals and nutrient deficiency.  I'm still working on eliminating the protozoan, but correcting the other stuff allows me to live a somewhat normal life. 

Eating alkaline foods is a must.  There is research enforcing my opinon.

Quote    Reply   
avatar

linenup

fanatic

Posts: 1,685

#3 [url]

Mar 1 16 12:05 AM

Thanks. I think the bigger issue is as you mentioned, the resistance. I found through many trials that certain things could eliminate them for a time but they quickly adapted and memorized the substance that killed them. Resistance is becoming a bigger issue as we read about this frequently. Hemp oil (Nutiva) (a good shot of it btw) along with goldenseal leaf (not root) has been a breakthrough for me. I went back on the remedies that started the killoff then failed, after adding the hemp/goldenseal then they began to work again. 

Thumbs up on the alalizing statement. I find quick resolution when using sodium bicarbonate. 

Quote    Reply   
Add Reply

Quick Reply

bbcode help