I did many pharmas and found the Nita/Paromomycin combo worked the best but they quickly resisted against that. I addressed the biofilm issue using lactoferrin with xylitol or just lactoferrin. Lactoferrin has the ability to kill off many pathogens by itself but is known for reducing the biofilm environment. If the biofilm environment is present then it is difficult for any antimicrobial to kill the infection off. You must take precautions and go slow, I have tutorials here to help.
The second issue is the resistance factor (if present) and with that I used goldenseal leaf (not root) and hemp oil from Nutiva.
Antimicrobials used: Caprylic acid, neem, graviola. These should be sufficient to start off with, I can provide additional products if these are not effective. Let me know if you have more questions.
*disclaimer: Since I am not a doctor, I am unable to diagnose or treat anyone, the information provided should be considered educational and should be shared with your healthcare provider.