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Jul 25 16 1:53 AM

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I wanted to share my experience with r lipoic acid. Toxicity is a continual issue for me due to the infection still brewing, I have reduced the infection quite a bit but still am suffering with oxidative stress. Immune cells produce strong oxidants that are fallout and produce oxides that kill or lyse the pathogens. As a result of the immune reactions, lots of damage occurs (oxidative), this oxidative damage then attacks healthy cells, mainly the cell membrane and mitochondria. When this happens, then degenerative disease patterns occur. 

There is growing awareness of mitochondrial diseases however it should be noted that the damage is due to oxidatvie stress. Reducing oxidative stress saves the cells from destruction. Aging is likely accelerated by this oxidative stress. I use a number of products that has been an experiment over a long period of time. Vitamins C & E are mainstays along with different binding agents such as chlorella, edta, zeolites and alkalizing agents (sodium bicarbonate or baking soda). I have experimented with a number of other products such as liposomal forms of glutathione and SOD (superoxide dismutase), the latter being chemicals that the body naturally produces. R lipoic acid is a great product and is another tool in the arsenal. The article (see link) says that it is neuroprotective, regulates cytokines and alters 'toxic genes'. Note that this is R lipoic and not lipoic. The studies are showing great promise. Here is an article that explains it in detail. http://nutritionreview.org/2013/04/rlipoic-acid/

 
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Jul 26 16 12:28 AM

I found this interesting statement about using wide spectrum antioxidants:

Use Antioxidants As A Team, Not Singularly
The current thinking is that antioxidants should be used together in a well researched way, not singularly. Dr. Lester Packer states, “Antioxidants are meant to work together, and in almost every circumstance, combinations of antioxidants have been proven to be more effective than single antioxidants.”

Dr. John Smythies in his book, Every Person’s Guide to Antioxidants, states, “Antioxidants should not be given singly because of the strong evidence of their team action. Because overloading with one may upset this delicate balance and lead to bad results, one should be skeptical about single antioxidants for sale on store shelves. The evidence clearly shows that antioxidants should not be consumed singly but only as well balanced mixtures of many antioxidants.”

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Aug 1 16 5:46 AM

Here is a response I made when asked about free radicals (oxidative stress.)

Sorry Carla, I didn't see this one. Antioxidants, Nitric oxide, and superoxide dis-mutase reduce free radicals. [sic] If we are low on manganese, then the superoxide dis-mutase won't bind free radicals like it is supposed to. If we are low on P5P or any of the B vitamins, that can reduce free radical binding. Our body works like it is supposed to in the beginning, but over time, we lose these nutrients and our diet is not replenishing them.

Here is the problem. We are causing the free radicals on purpose. The harmful free radicals like peroxynitrite and superoxide (just to name two) are caused by us to kill pathogens. Nitric oxide also kills pathogens. The problem occurs when our biological pathways break down from lack of items like biopterin, cobalamin, folate, manganese, magnesium, and sometimes copper. When this happens, our body has too many free radicals floating around and can't stop them because we've run low on these elements. Our body does the only thing it can do to save itself, gene mutation. This down regulates our immune response. That is why epigenetic shifts in CBS, VDR, SOD, MTHFR, and MTRR occur. By doing this, we make less nitric oxide and glutathione (which are both good) but if we can't get rid of the next line of products produced. We end up with more cellular damage from peroxynitrite and superoxide. Supplementing with manganese, copper, etc can cause more oxidative stress because it revs up our pathways but our systems have down regulated and we don't have a system in place to support a revved up immune system. We start making more NO which makes more peroxynitrite and superoxide and we kill more pathogens. We just can't handle the toxins and debris left in their wake. Detoxing is a direct effect of our immune response and when it is down regulated, our detoxing is down regulated.

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Aug 1 16 11:47 PM

Thanks for the good post - I never thought about the idea of down regulating , makes sense. What do you know about the role of ROS in cell signaling?

The "two-faced" character of ROS is substantiated by growing body of evidence that ROS within cells act as secondary messengers in intracellular signalling cascades,

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