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Leaky gut is caused by high oxidative stress. The oxidative stress is caused by the immune responses caused by pathogens. The lumen of the gut is subject to this oxidative stress in which holes are created in the gut allowing undigested proteins to enter the bloodstream thus causing more inflammation. When the lining of the gut is damaged, a major rebuild effort is required by the body.
This article covers the use of butyrate in inflammatory bowel conditions http://www.medicalnewstoday.com/articles/268786.php