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May 25 15 9:18 PM

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Minerals play key roles in performing functions in the body. Nutritional science has proven over and over again that nutrition is a major component in disease. Mineral balance plays a key role and by this I mean that minerals have antagonistic and agonistic relationships with each other. For instance copper and zinc have this role, where if one is excessive, the other will be subordinate. It is important to keep minerals in balance. 

Here is a nice article on minerals http://www.herbs2000.com/minerals/1_minerals.htm
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May 27 15 4:25 AM

I often communicate with physicians to better my understanding of our problems.  I had a slight disagreement with one of them and this is what I sent him the other day.  I have since found other references to back my claims even further.  I think a depletion of divalent cations contributes or even causes our problems.  Cobalt and chromium are both potentially toxic metals that are vital to our functioning.  The process I describe below will deplete both.  If not replenished, our functioning will suffer.  We don't eat enough nutrients to replenish our deficiencies because our pathogens are depleting us daily.  It took Terry Wahls 8 months to get hers back and we're not eating as good as she is. 

I look at things from a biochemical standpoint.  Can borrelia excrete both quinolinic acid and ammonia?  I do not believe the bacteria is capable of doing this.  After much research and study, here is my proposed etiology of ammonia formation during a borrelia infection.   LPS detection increases polyamine production and nitric oxide (NO) formation as one of the initial steps of the cytokine cascade.  Tetrahydrobiopterin (BH4) levels are diminished as they are used to make NO.  As BH4 levels drop, the neurotransmitter pathway has diminished efficiency and is further compounded as the activation of macrophages pushes biopterin to neopterin due to microglial stimulation.  We know this decreases methionine synthase(MTR) by ~80% as well.  Because of increased Th2 cytokines, Arg1 converts Arginine to ornithine and ornithine decarboxylase causes ornithine to convert to putrescine which is then converted to spermidine and then spermine.  These nitrogen rich proteins greatly affect the ornithine cycle and decreases the ability to convert Citrulline back to Arginine.  Arginine levels decrease and the excess nitrogen in the ornithine cycle can not all be converted to urea and becomes ammonia.  I have hypothesized that this is a defense mechanism of the body to combat excess acidity but have not explored that hypothesis at this time.  It would be similar to Sickle Trait vs Sickle Cell where a change is made in an attempt to lengthen survival.   The ammonia build up is compounded as MTR is decreased by 80%, this also decreases SAMe production.  As the entire methylation pathway's efficiency diminishes and the body becomes even more stressed with an increasing lower pH burden and the Transsulfuration pathway shunts cystathionine degradation to alpha ketoglutarate and ammonia (dependent upon cysteine intake and serine availability.)  A CBS upregulation can often be seen upon studying the epigentics of the patient as well as lithium and iodine deficiencies.   Further compounding this condition is the fact that the aliphatic polyamines bind all available divalent cations and because of this, they are moved extracellular and become depleted.  The main cations I have seen diminished are manganese, magnesium, selenium, zinc, molybdenum, chromium, boron, and even copper.  Copper is interesting and in a different category from the others IMO.  All of this combines to allow for ammonia formation due to decreased efficiencies of the Ornithine, Neurotransmitter, Methionine, and Transsulfuration pathways. 

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May 31 15 3:34 AM

Interesting work - trying to catch up :) - basically what you are saying is that the infections begin a cascade of biochemical events, a chain reaction. One event triggers the next and so on. And because of these reactions, the biochemistry of many systems become dysregulated. Because of this dysregulation, the body becomes depleted of vital nutrients and in order to keep up, it is vital to replenish the body.

Of all the diseases I have studied, these immune based ones are the most difficult due to the amount of biochemical reactions that take place, I think this is what you are saying. Immune triggers the endocrine response and affects the neurological responses as well. I think that we could include damage on the cellular level where cell membranes are badly damaged from the infections leading to something Dr. Majid Ali called it 'leaky cell syndrome'. He remarks that CFS patients have badly damaged cell membranes due to the high oxidative stress leading to poor electron transfer which means poor energy. Poor cell functioning leads to decreased production of vital hormones, enzymes, detoxification and so on.

Interesting video on oxidative stress and cell membranes with an emphasis on mitochondria 

Last Edited By: linenup May 31 15 4:06 AM. Edited 1 time.

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May 31 15 4:20 AM

While watching this video I was thinking about the natural antioxidants we produce such as Glutathione, SuperOxide Dismutase and Catalase. All powerful chemicals to assist against free radicals and all dependent on nutrients to be created. All require minerals, vitamin co-factors and proteins to be produced, SOD requires manganese, copper and zinc

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May 31 15 6:26 AM

linenup wrote:
While watching this video I was thinking about the natural antioxidants we produce such as Glutathione, SuperOxide Dismutase and Catalase. All powerful chemicals to assist against free radicals and all dependent on nutrients to be created. All require minerals, vitamin co-factors and proteins to be produced, SOD requires manganese, copper and zinc
 

Exactly.  I have a mutation to SODII and I think it was my body's attempt to slow down oxidative stress because I was deficient of Mn and Cu.  It causes cherry angiomas for those that are interested.  Looking at the methylation pathway (which is vital for everything), Mg, Zn, Bo, Mb, and Mn are all vital to pathway functioning.  Here is the kicker, pathogens do not have internal processes for them to manufacture these elements.  They contain metallothioneins that allow them to steal them from their environment.  These metallotheioneins will either grab these transition metals or they can grab heavy metals like Pb and Hg.  This often decreases our immune response and helps increase pathogen survival.  It also helps block the methylation pathway which further hurts our recovery efforts.  Aluminum is a huge problem and most of those with GERD are experiencing it first hand. 

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Jun 3 15 2:11 AM

I have read that some colonies of pathogens will use the SOD/Glutathione as means to feed the colonies which has always confused me since these are vital nutrients for the human body. Cysteine I have heard is another feeder since it is a primary amino acid. Perhaps the answer is finding ways to eradicate the pathogens and all of this goes away :)

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Jun 8 15 2:46 AM

Is there a specific post you are referring to? 

Excellent books for mineral information:

1/ Rare Earths - Forbidden Cures  by Dr. Joel Wallachhttp://www.amazon.com/Rare-Earths-Forbidden-Ma-Lan/dp/0970149085  ($20)

2/ Dr. David Watts PhD  =16pxTRACE ELEMENTS AND OTHER ESSENTIAL NUTRIENTS http://traceelements.com/EducationalResources/BookStore.aspx  ($20)

3/ Understanding Vitamins and MInerals by Prevention  http://www.amazon.com/Understanding-Vitamins-Minerals-Prevention-Health/dp/0878574638/ref=sr_1_1?s=books&ie=UTF8&qid=1433756635&sr=1-1&keywords=prevention+minerals ($5)

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Jun 14 15 2:22 AM

An interesting article from the CriticalHealthNews.com site...SICK SOIL“You can trace every sickness, every disease and every ailment to a mineral deficiency.”- Dr. Linus Pauling, two-time Nobel Prize winner“Sick soils mean sick plants, sick animals and sick people.”Soil in the US has become depleted and deficient in nutrients. It has been known since 1936 that we are eating an empty harvest.“Most of us today are suffering from certain dangerous diet deficiencies which cannot be remedied until the depleted soils from which our foods come are brought into proper mineral balance. The alarming fact is that foods, fruits and vegetables and grains, now being raised on millions of acres of land that no longer contain enough of certain needed minerals, are starving us - no matter how much of them we eat!”“Countless human ills stem from the fact that impoverished soil of America no longer provides plant foods with the mineral elements essential to human nourishment and health!”Download: United States Senate Document #264 (.pdf file)
Printed in US Congress in 1936Scientific studies show that there has been a dramatic reduction or elimination of critical and essential minerals from fields due to over harvesting, chemical pollution, pesticides and other harmful farming practices; stripping soils of minerals. Mineral deficiencies in the diet have been identified as the cause of many modern diseases including cancer, heart disease and obesity.The chart below clearly shows the correlation between decreasing soil borne minerals coincidental with the increase of mineral deficient disease in people.Research conducted at major Universities and government agencies offer compelling findings that indicate an overall mineral deficiency condition in the soil of the nation’s croplands:University of Texas - Donald Davis, a senior researcher at the University of Texas, performed research into the disappearing nutrients in food. He compared Agriculture Department figures on nutrient content for 43 common fruits and vegetables. Davis says historical data spanning 50 to 70 years show apparent declines of 5 percent to 40 percent or more in minerals, vitamins and proteins in vegetables.Washington State University - Professor Stephen Jones and researcher Kevin Murphy. Research showed that today’s modern wheat has less nutritional value concluding that grains have been developed for baking qualities that are related to protein, not related to iron and zinc and selenium and other essential vitamins and minerals. “You would have to eat twice as many slices of modern bread as you would of the older variety to get the same nutritional value.”2001. The Journal of Complimentary Medicine - pointed out that the US and UK Government statistics show a decline in trace minerals of up to 76% in fruit and vegetables over the period 1940 to 1991.2003. News Canada - reported that today’s fruit and vegetables contain far fewer nutrients than they did 50 years ago. Potatoes, for example, had lost 100 % of vitamin A content, 57% of vitamin C and iron, and 28% of calcium. The report examined data from the US Department of Agriculture involving vegetable quality. Over the entire 20th century the average mineral content in cabbage, lettuce, spinach and tomatoes, declined from 400mg to less than 50mg.2004. The Journal of the American College of Nutrition - examined food composition changes from 1950 to 1999 recorded in the USDA food composition tables. Forty-three crops were examined showing statistically reliable declines for 6 nutrients. The declines were observed in protein, calcium, phosphorous, iron, riboflavin and ascorbic acid; 6% in the case of protein and 38% for riboflavin.2008. The UK publication Food Magazine - Analysis of food quality changes in the UK over the period 1940-2002. In an analysis of milk: iron content had fallen 62%; magnesium was down 21%; copper content had disappeared completely. Parmesan cheese had a 70% decrease in magnesium. The calcium and iron content of all the foods examined was reduced dramatically. Beef rump steak iron content fell 55%.

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